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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually focused on the practical aspects of the study design, such as recruitment and consent, adherence, and the use of commonly available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be valid and also helps reduce bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.
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프라그마틱 추천 of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be a great method of determining the causality between an intervention and its results. However, they should not be used to substitute for explanation trials.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a practical trial that include the recruitment process, the design and implementation of the intervention, as well as follow-up.
There is a growing trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health science community is becoming more sensitive to the issue of pragmatics. It is important to note that the majority of these studies were conducted in primary-care settings.