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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of research design, like recruitment and consent in adherence, as well as the use of commonly available equipment.
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Pragmatic is a software development company that provides a variety of casino games available on online gambling platforms. Pragmatic's iGaming solutions are utilized by the leading operators and casinos that are located in the land. The company provides front-end design tools, analysis tools, marketing, promotions and payment systems, as well as security, customer service and bug reporting. The company also offers a safe environment with high-quality graphics, gaming and security.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. A high degree of heterogeneity, however can result in problems with the design of the trial.
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Legality
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers to help guide their decisions. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used to replace explanatory studies.
The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study, including the recruitment, design, and delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember, however, that the majority were conducted in primary-care settings.